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News:
Improved
Antibody cocktail
induces arthritis within
days offering a
time-saving alternative
to the classic CIA
model.
MD Biosciences, a global
biotechnology company
focused in inflammations
research, announces the
recent launch of its new
and improved
ArthritoMab(TM) Antibody
Cocktail for the
induction of arthritis.
This monoclonal antibody
cocktail, developed by
Prof. Rikard Holmdahl
and licensed to Morwell
Diagnostics (parent
company of MD
Biosciences), offers
many improvements over
other arthritis inducing
cocktails such as a
flexible protocol design
for the study of TLR
dependent or independent
disease pathology and
severe arthritis
observed in front and
rear paws.
The ArthritoMab(TM)
Antibody Cocktail is
comprised of 4
monoclonal antibodies to
collagen type II (CII)
that have been chosen
for their epitope
specificity. An antibody
response to certain
epitopes is better
associated with
arthritis than a
response to other
epitopes. In the
collagen-induced
arthritis (CIA) model,
the antibody response
correlated with
arthritis was mainly
associated with binding
to the epitopes C1, J1,
and U1. The ArthritoMab™
monoclonal antibodies
were selected to bind to
the epitopes C1, J1, U1
and D3 - which are
spread over the entire
CII region (fragments
CB8, CB10 and CB11)
encouraging better
immune complex formation
on the cartilage surface
for the initiation of
arthritis.
Read
entire press release....
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Download Resources:
Whitepaper
ArthritoMab(TM)
Publication
ArthritoMab(TM)
Insert (Cat #
CIA-MAB-50)
Get a
quote
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a service
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